Selected papers

Zhang, K., Julius, D., and Cheng, Y. 2021. Structural snapshots of TRPV1 reveal mechanism of polymodal functionality, Cell, 184: 5138-5150 e12. Link

Zhang, K., Wu, H., Hoppe, N., Manglik, A., and Cheng, Y. 2022. Fusion protein strategies for cryo-EM study of G protein-coupled receptors, Nat Commun, 13: 4366. Link

Zhang, K.*, Zhang, J.*, Gao, Z.G., Zhang, D., Zhu, L., Han, G.W., Moss, S.M., Paoletta, S., Kiselev, E., Lu, W., Fenalti, G., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., and Zhao, Q. 2014. Structure of the human P2Y12 receptor in complex with an antithrombotic drug, Nature, 509: 115-8. (*, co-first author) Link

Zhang, J.*, Zhang, K.*, Gao, Z.G., Paoletta, S., Zhang, D., Han, G.W., Li, T., Ma, L., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., and Zhao, Q. 2014. Agonist-bound structure of the human P2Y12 receptor, Nature, 509: 119-22. (*, co-first author) Link

Zhang, K., Julius, D., and Cheng, Y. 2022. A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM, STAR Protoc, 3: 101732. Link

Zhou, X.X., Bracken, C.J., Zhang, K., Zhou, J., Mou, Y., Wang, L., Cheng, Y., Leung, K.K., and Wells, J.A. 2020. Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps, J Am Chem Soc, 142: 17703-17713. Link

Zhang, D., Gao, Z.G., Zhang, K., Kiselev, E., Crane, S., Wang, J., Paoletta, S., Yi, C., Ma, L., Zhang, W., Han, G.W., Liu, H., Cherezov, V., Katritch, V., Jiang, H., Stevens, R.C., Jacobson, K.A., Zhao, Q., and Wu, B. 2015. Two disparate ligand-binding sites in the human P2Y1 receptor, Nature, 520: 317-21. Link

Faust, B., Billesbolle, C.B., Suomivuori, C.M., Singh, I., Zhang, K., Hoppe, N., Pinto, A.F.M., Diedrich, J.K., Muftuoglu, Y., Szkudlinski, M.W., Saghatelian, A., Dror, R.O., Cheng, Y., and Manglik, A. 2022. Autoantibody mimicry of hormone action at the thyrotropin receptor, Nature, 609: 846-853. Link

Schoof, M., Faust, B., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesbolle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Deshpande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Consortium, Q.S.B., Walter, P., and Manglik, A. 2020. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike, Science, 370: 1473-1479. Link

Gordon, D.E., Hiatt, J., Bouhaddou, M., Rezelj, V.V., Ulferts, S., Braberg, H., Jureka, A.S., Obernier, K., Guo, J.Z., Batra, J., Kaake, R.M., Weckstein, A.R., Owens, T.W., Gupta, M., Pourmal, S., Titus, E.W., Cakir, M., Soucheray, M., McGregor, M., Cakir, Z., Jang, G., O’Meara, M.J., Tummino, T.A., Zhang, Z., Foussard, H., Rojc, A., Zhou, Y., Kuchenov, D., Huttenhain, R., Xu, J., Eckhardt, M., Swaney, D.L., Fabius, J.M., Ummadi, M., Tutuncuoglu, B., Rathore, U., Modak, M., Haas, P., Haas, K.M., Naing, Z.Z.C., Pulido, E.H., Shi, Y., Barrio-Hernandez, I., Memon, D., Petsalaki, E., Dunham, A., Marrero, M.C., Burke, D., Koh, C., Vallet, T., Silvas, J.A., Azumaya, C.M., Billesbolle, C., Brilot, A.F., Campbell, M.G., Diallo, A., Dickinson, M.S., Diwanji, D., Herrera, N., Hoppe, N., Kratochvil, H.T., Liu, Y., Merz, G.E., Moritz, M., Nguyen, H.C., Nowotny, C., Puchades, C., Rizo, A.N., Schulze-Gahmen, U., Smith, A.M., Sun, M., Young, I.D., Zhao, J., Asarnow, D., Biel, J., Bowen, A., Braxton, J.R., Chen, J., Chio, C.M., Chio, U.S., Deshpande, I., Doan, L., Faust, B., Flores, S., Jin, M., Kim, K., Lam, V.L., Li, F., Li, J., Li, Y.L., Li, Y., Liu, X., Lo, M., Lopez, K.E., Melo, A.A., Moss, F.R., 3rd, Nguyen, P., Paulino, J., Pawar, K.I., Peters, J.K., Pospiech, T.H., Jr., Safari, M., Sangwan, S., Schaefer, K., Thomas, P.V., Thwin, A.C., Trenker, R., Tse, E., Tsui, T.K.M., Wang, F., Whitis, N., Yu, Z., Zhang, K., Zhang, Y., Zhou, F., Saltzberg, D., Consortium, Q.S.B., Hodder, A.J., Shun-Shion, A.S., Williams, D.M., White, K.M., Rosales, R., Kehrer, T., Miorin, L., Moreno, E., Patel, A.H., Rihn, S., Khalid, M.M., Vallejo-Gracia, A., Fozouni, P., Simoneau, C.R., Roth, T.L., Wu, D., Karim, M.A., Ghoussaini, M., Dunham, I., Berardi, F., Weigang, S., Chazal, M., Park, J., Logue, J., McGrath, M., Weston, S., Haupt, R., Hastie, C.J., Elliott, M., Brown, F., Burness, K.A., Reid, E., Dorward, M., Johnson, C., Wilkinson, S.G., Geyer, A., Giesel, D.M., Baillie, C., Raggett, S., Leech, H., Toth, R., Goodman, N., Keough, K.C., Lind, A.L., Zoonomia, C., Klesh, R.J., Hemphill, K.R., Carlson-Stevermer, J., Oki, J., Holden, K., Maures, T., Pollard, K.S., Sali, A., Agard, D.A., Cheng, Y., Fraser, J.S., Frost, A., Jura, N., Kortemme, T., Manglik, A., Southworth, D.R., Stroud, R.M., Alessi, D.R., Davies, P., Frieman, M.B., Ideker, T., Abate, C., Jouvenet, N., Kochs, G., Shoichet, B., Ott, M., Palmarini, M., Shokat, K.M., Garcia-Sastre, A., Rassen, J.A., Grosse, R., Rosenberg, O.S., Verba, K.A., Basler, C.F., Vignuzzi, M., Peden, A.A., Beltrao, P. and Krogan, N.J. 2020. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms, Science, 370. Link